Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling

Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling.

Ethenzamide solids as a representative active pharmaceutical ingredient (API) were batch-ground by means of a fluidized-bed jet-mill which is a relatively new equipment and promising for production in the pharmaceutical field. Thus, the characteristic grinding mechanism was investigated. As a result, the variation of the residual ratio with grinding time after milling was expressed simply by a ...

Variation in particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling.

In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficientl...

Hydrodynamic Behavior of Particles in a Jet Flow of a Gas Fluidized Bed

Numerous investigations have been devoted towards understanding the hydrodynamics of gas jets in fluidized beds. However, most of them address the problem from  macroscopic point of view, which does not reveal the true behavior in the jet region at the single particle level. The present work aims to understand the jet behavior from a more fundamental level, i.e. the individual particle leve...

hydrodynamic behavior of particles in a jet flow of a gas fluidized bed

numerous investigations have been devoted towards understanding the hydrodynamics of gas jets in fluidized beds. however, most of them address the problem from  macroscopic point of view, which does not reveal the true behavior in the jet region at the single particle level. the present work aims to understand the jet behavior from a more fundamental level, i.e. the individual particle level. a...

Effect of Process Variables on Growth Kinetics of Lactose Particles in a Wet Spray Fluidized Bed Granulator